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PROTAC Linkers Related Products (1535)
Related Products (1535)
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4-Azidobutylamine
0 Images4-Azidobutylamine is a PROTAC linker, which refers to the alkyl chain composition. 4-Azidobutylamine can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. 4-Azidobutylamine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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tert-Butyl (8-aminooctyl)carbamate
0 ImagesCat. No.: HY-42773CAS No.: 88829-82-7Synonyms: 1-Boc-1,8-diaminooctanetert-Butyl (8-aminooctyl)carbamate (1-Boc-1,8-diaminooctane) can be used as a PROTAC linker in the synthesis of PROTACs. tert-butyl (8-aminooctyl)carbamate is an alkane chain with terminal amine and Boc-protected amino groups. Amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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4-Bromobutanoic acid tert-butyl ester
0 ImagesSynonyms: tert-Butyl 4-Bromobutyrate
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tert-Butyl 5-aminopentanoate
0 ImagesCat. No.: HY-W074340CAS No.: 63984-03-2
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tert-Butyl 3-oxoazetidine-1-carboxylate
0 ImagesSynonyms: N-Boc-3-azetidinonetert-Butyl 3-oxoazetidine-1-carboxylate is a synthetic intermediate. tert-Butyl 3-oxoazetidine-1-carboxylate can be used in compound research and development targeting cancer and tuberculosis.
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NH2-C6-NH-Boc
0 ImagesNH2-C6-NH-Boc is a PROTAC linker which refers to the alkyl/ether composition. NH2-C6-NH-Boc can be used in the synthesis the Mcl-1 inhibitor based on PROTAC.
![7-Boc-(2,7-Diazaspiro[3.5]nonane)](https://file.medchemexpress.com/product_pic/hy-30755.gif "Click to View 7-Boc-(2,7-Diazaspiro[3.5]nonane) Product Detail")
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10-Hydroxydecanoic acid
0 Images10-Hydroxydecanoic acid (10-HDAA) is a saturated fatty acid derived from 10-hydroxy-trans-2-decenoic acid, which can be isolated from royal jelly. 10-Hydroxydecanoic acid exhibits various biological activities, including anti-inflammatory, insecticidal, anti-malarial, and anti-Leishmania properties, as well as enhancing antigen-specific immune responses. The anti-inflammatory effects of 10-Hydroxydecanoic acid are primarily mediated by inhibiting the activation of NF-κB and the translation of interferon regulatory factor 1 (IRF-1), which reduces the production of interleukin 6 (IL-6) and nitric oxide (NO) in inflammatory cells. Additionally, 10-Hydroxydecanoic acid alleviates neuroinflammatory responses through the p53-autophagy pathway and the p53-NLRP3 pathway. Finally, 10-Hydroxydecanoic acid enhances antigen-specific immune responses by promoting the effective uptake of antigens by microfold cells.
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4-Azidobutyric acid
0 Images4-Azidobutyric acid is a click chemistry reagent featuring azide and carboxylic acid moieties. The carboxylic acid group can conjugate with alcohols or amides, while the azide group serves as a click chemistry handle to react with terminal alkynes or strained cyclooctynes. 4-Azidobutyric acid also acts as a PROTAC linker for the synthesis of PROTACs.
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Hex-5-yn-1-ol
0 ImagesSynonyms: 5-Hexyn-1-ol
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tert-Butyl 9-oxo-3-azaspiro[5.5]undecane-3-carboxylate
![tert-Butyl 9-oxo-3-azaspiro[5.5]undecane-3-carboxylate](https://file.medchemexpress.com/product_pic/hy-w043503.gif "Click to View tert-Butyl 9-oxo-3-azaspiro[5.5]undecane-3-carboxylate Product Detail")
0 ImagesCat. No.: HY-W043503CAS No.: 873924-08-4
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TLR4-IN-C34-C2-COOH
0 ImagesTLR4-IN-C34-C2-COO is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34-C2-COOH can be used in the research of inflammation and acute myocardial injury. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis.
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6-Bromohexanoic acid
0 ImagesSynonyms: 6-bromohexanoate
